Below is a listing of all the major shortcut keys in Microsoft Outlook. See the computer shortcut page if you are looking for other shortcut keys used in other programs.
| Shortcut Keys | Description |
| Alt + S | Send the e-mail |
| Ctrl + Enter | Send the e-mail you’re composing. |
| Ctrl + C | Copy selected text. |
| Ctrl + X | Cut selected text. |
| Ctrl + P | Print selected text. |
| Ctrl + K | Complete the name or e-mail being typed in the e-mail address bar. |
| Ctrl + B | Bold highlighted selection |
| Ctrl + I | Italic highlighted selection |
| Ctrl + M | Send and receive all |
| Ctrl + U | Underline highlighted selection |
| Ctrl + R | Reply to an e-mail. |
| Ctrl + F | Forward an e-mail. |
| Ctrl + N | Create a new e-mail. |
| Ctrl + Y | Go to folder. |
| Ctrl + Shift + A | Create a new appointment to your calendar. |
| Ctrl + Shift + O | Open the Outbox. |
| Ctrl + Shift + I | Open the Inbox. |
| Ctrl + Shift + K | Add a new task. |
| Ctrl + Shift + C | Create a new contact. |
| Ctrl + Shift + J | Create a new journal entry. |
| Ctrl + Shift + V | Move folder. |